Table of Contents
October 24, 2002
Volume 45, Issue 22
Pages 4801-4946
About the Cover: Model of the histone deacetylase inhibitor, 3-(4-benzoyl-1-methyl-1H-2-pyrrole)-N-hydroxy-
Letters
Design and Synthesis of Tricyclic Compounds with Enone Functionalities in Rings A and C: A Novel Class of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages
Frank G. Favaloro, Jr., Tadashi Honda, Yukiko Honda, Gordon W. Gribble, Nanjoo Suh, Renee Risingsong, and Michael B. Sporn
pp 4801–4805Publication Date (Web): September 24, 2002 (Letter)
DOI: 10.1021/jm025565f
Hi-Res PDF Articles
Benzimidazole Derivatives. 3. 3D-QSAR/CoMFA Model and Computational Simulation for the Recognition of 5-HT4 Receptor Antagonists
María L. López-Rodríguez, Marta Murcia, Bellinda Benhamú, Alma Viso, Mercedes Campillo, and Leonardo Pardo
pp 4806–4815Publication Date (Web): October 01, 2002 (Article)
DOI: 10.1021/jm020807x
Inhibitory Mode of 1,5-Diarylpyrazole Derivatives against Cyclooxygenase-2 and Cyclooxygenase-1: Molecular Docking and 3D QSAR Analyses
Hong Liu, Xiaoqin Huang, Jianhua Shen, Xiaomin Luo, Minghui Li, Bing Xiong, Gang Chen, Jingkang Shen, Yimin Yang, Hualiang Jiang, and Kaixian Chen
pp 4816–4827Publication Date (Web): September 24, 2002 (Article)
DOI: 10.1021/jm020089e
Comparative Binding Energy (COMBINE) Analysis of OppA−Peptide Complexes to Relate Structure to Binding Thermodynamics
Ting Wang and Rebecca C. Wade
pp 4828–4837Publication Date (Web): September 21, 2002 (Article)
DOI: 10.1021/jm020900l
κ-Opioid Receptor Model in a Phospholipid Bilayer: Molecular Dynamics Simulation
Manuela Iadanza, Monika Höltje, Giuseppe Ronsisvalle, and Hans-Dieter Höltje
pp 4838–4846Publication Date (Web): September 27, 2002 (Article)
DOI: 10.1021/jm0209127
Computer-Aided Design of Selective COX-2 Inhibitors: Comparative Molecular Field Analysis, Comparative Molecular Similarity Indices Analysis, and Docking Studies of Some 1,2-Diarylimidazole Derivatives
G. R. Desiraju, B. Gopalakrishnan, R. K. R. Jetti, A. Nagaraju, D. Raveendra, J. A. R. P. Sarma, M. E. Sobhia, and R. Thilagavathi
pp 4847–4857Publication Date (Web): September 20, 2002 (Article)
DOI: 10.1021/jm020198t
Three-Dimensional Quantitative Structure−Activity Relationship of 1,4-Dihydropyridines As Antitubercular Agents
Prashant S. Kharkar, Bhavik Desai, Harsukh Gaveria, Bharat Varu, Rajesh Loriya, Yogesh Naliapara, Anamik Shah, and Vithal M. Kulkarni
pp 4858–4867Publication Date (Web): October 02, 2002 (Article)
DOI: 10.1021/jm020217z
Quantitative Structure−Activity Relations for γδ T Cell Activation by Phosphoantigens
William Gossman and Eric Oldfield
pp 4868–4874Publication Date (Web): September 19, 2002 (Article)
DOI: 10.1021/jm020224n
Synthesis, Molecular Modeling Studies, and Pharmacological Activity of Selective A1 Receptor Antagonists
Francesco Bondavalli, Maurizio Botta, Olga Bruno, Andrea Ciacci, Federico Corelli, Paola Fossa, Antonio Lucacchini, Fabrizio Manetti, Claudia Martini, Giulia Menozzi, Luisa Mosti, Angelo Ranise, Silvia Schenone, Andrea Tafi, and Maria Letizia Trincavelli
pp 4875–4887Publication Date (Web): September 24, 2002 (Article)
DOI: 10.1021/jm0209580
Stereoselective Synthesis and Antiviral Activity of d-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides
Youhoon Chong, Hyunah Choo, Yongseok Choi, Judy Mathew, Raymond F. Schinazi, and Chung K. Chu
pp 4888–4898Publication Date (Web): September 24, 2002 (Article)
DOI: 10.1021/jm020246+
Full Text HTMLThe Structure of Erythromycin Enol Ether as a Model for Its Activity as a Motilide
Wayne E. Steinmetz, Brett L. Shapiro, and John J. Roberts
pp 4899–4902Publication Date (Web): October 01, 2002 (Article)
DOI: 10.1021/jm020250l
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole
Armando Rossello, Simone Bertini, Annalina Lapucci, Marco Macchia, Adriano Martinelli, Simona Rapposelli, Esperanza Herreros, and Bruno Macchia
pp 4903–4912Publication Date (Web): September 26, 2002 (Article)
DOI: 10.1021/jm020980t
Array-Based Structure and Gene Expression Relationship Study of Antitumor Sulfonamides Including N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide
Takashi Owa, Akira Yokoi, Kanami Yamazaki, Kentaro Yoshimatsu, Takao Yamori, and Takeshi Nagasu
pp 4913–4922Publication Date (Web): September 24, 2002 (Article)
DOI: 10.1021/jm0201060
Novel σ Receptor Ligands. Part 2. SAR of Spiro[[2]benzopyran-1,4‘-piperidines] and Spiro[[2]benzofuran-1,4‘-piperidines] with Carbon Substituents in Position 3
Christoph A. Maier and Bernhard Wünsch
pp 4923–4930Publication Date (Web): October 02, 2002 (Article)
DOI: 10.1021/jm020889p
Synthesis and Antitumor Activity of New Derivatives of Xanthen-9-one-4-acetic Acid
Silvia Gobbi, Angela Rampa, Alessandra Bisi, Federica Belluti, Piero Valenti, Anna Caputo, Antonella Zampiron, and Maria Carrara
pp 4931–4939Publication Date (Web): September 24, 2002 (Article)
DOI: 10.1021/jm020929p
Synthesis, Stability, and Antimalarial Activity of New Hydrolytically Stable and Water-Soluble (+)-Deoxoartelinic Acid
Mankil Jung, Kyunghoon Lee, Howard Kendrick, Brian L. Robinson, and Simon L. Croft
pp 4940–4944Publication Date (Web): September 10, 2002 (Article)
DOI: 10.1021/jm020244p
Book Reviews
Ions in Biological Systems. Volume 39. Molybdenum and Tungsten: Their Roles in Biological Processes Edited by Astrid Sigel and Helmut Sigel. Marcel Dekker, New York. 2002. lix + 810 pp. 16 × 23.5 cm. ISBN 0-8247-0765-6. $250.00.
John R. J. Sorenson
p 4945Publication Date (Web): August 29, 2002 (Book Review)
DOI: 10.1021/jm0202627
Additions and Corrections
Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation.
Le Wang, Keith W. Woods, Qun Li, Kenneth J. Barr, Richard W. McCroskey, Steven M. Hannick, Laura Gherke, R. Bruce Credo, Yu-Hua Hui, Kennan Marsh, Robert Warner, Jang Y. Lee, Nicolette Zielinski-Mozng, David Frost, Saul H. Rosenberg, and Hing L. Sham:
p 4946Publication Date (Web): September 19, 2002 (Addition/Correction)
DOI: 10.1021/jm020332+